Regeneron is integrating single-use chromatographic clarification into its commercial-scale process for manufacturing adeno-associated vectors (AAVs), which enables it to eliminate endonuclease in ...

Apurinic/apyrimidinic endonuclease 1 (APE1), also known as Ref-1, performs critical dual functions as both a DNA repair enzyme and a redox signalling regulator. Within the base excision repair pathway ...

Flap endonuclease 1 (FEN1) is an essential DNA repair enzyme whose roles in replication and genomic maintenance have made it a critical target in cancer research. Elevated levels of FEN1 have been ...

Homologous recombination is a DNA repair mechanism that counteracts double-stranded breaks in DNA. Researchers at Kindai University have recently revealed how the Sae2 protein coordinates with the ...

The Scripps Research Institute has identified new baloxavir analogues and their prodrugs acting as new influenza cap-dependent endonuclease (CEN) inhibitors potentially useful for the treatment of ...