A research group has revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease. Crohn's disease is an intractable disorder characterized ...

Research into transcription factors deepen understanding of the 'language' of the genome, offering insights into human development. New research has uncovered more about the complexity of human gene ...

A key protein, HOXD13, helps melanoma tumors grow and evade the immune system by boosting blood supply and blocking cancer-fighting T cells. Disabling it shrinks tumors and reopens the door for the ...

Researchers at Lund University have mapped, in unprecedented detail, the epigenome of pancreatic cells regulating blood sugar, revealing how DNA methylation changes impair insulin and glucagon ...

Scientists have discovered how two transcription factors form a reciprocal regulatory circuit that controls T-cell exhaustion and migration during viral infection, which may inform future therapeutic ...

PA2G4 drives keratinocyte growth in psoriasis, highlighting a promising new treatment target. Find out more about this ...

Neuronal specification, expansion and differentiation are tightly regulated by the concerted actions of transcription and chromatin modifying factors that are recruited to regulatory elements in the ...

With a new study in the journal Cell, researchers at Stanford University and Stockholm University have contributed to increased knowledge about gene regulation in human cells. How genes are turned on ...

However, details of the intervening steps, as researchers have learned in the past 65 years, are quite complex — certain cells carry the flu antigen to the immune system, specific immune cells respond ...

Transcription Factors (TFs) are pivotal regulators of gene expression and have been implicated in a variety of diseases, including cancer, neurological disorders, autoimmune conditions, and metabolic ...